Abstract Background Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages. but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues. Results Here. we use computational modeling and single-cell genomics to thoroughly interrogate the origin and clonal dynamics of mtDNA variants acros... https://pipingrockers.shop/product-category/cleavers/